RAPID COMMUNICATION Murine Thrombopoietin mRNA Levels Are Modulated by Platelet Count

نویسنده

  • Kenneth Kaushansky
چکیده

The activity of the c-Mpl ligand on hematopoietic progenitors meets criteria expected for thrombopoietin (TPO). Bioassays have shown that blood TPO levels are inversely related to platelet mass. We sought to identify the molecular basis for this regulation. To determine if TPO mRNA levels respond to platelet demand, RNA from selected organs of mice with high, normal, or low platelet counts was subjected to semiquantitative reverse transcriptase-polymerase chain reaction. Although no differences in TPO mRNA levels between control and treated mice could be detected in liver

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Murine thrombopoietin mRNA levels are modulated by platelet count.

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تاریخ انتشار 2002